Spinal Substance P and CGRP staining in vincristine, cisplatin, streptozocin or constriction injury-induced neuropathies
نویسندگان
چکیده
Substance P and CGRP-expressing neurons were quantified in dorsal horn of rats suffering from painful neuropathy after toxic-, metabolicor chirurgically-induced injury. The CGRP immunoreactivities were increased in both models and the highest values were in diabetic and vincristine-induced rats. Immunostaining showed increase in SP immunoreactivity in diabetic rats. This study shows injury type-specific SP and CGRP liberation according to the etiology and delay after induction.
منابع مشابه
Upregulation of substance P in low-threshold myelinated afferents is not required for tactile allodynia in the chronic constriction injury and spinal nerve ligation models.
It has been proposed that substance P and calcitonin gene-related peptide (CGRP) are upregulated in low-threshold myelinated primary afferents after certain types of nerve injury, and that release of substance P from these afferents contributes to the resulting tactile allodynia. To test this hypothesis, we looked for neuropeptides in Abeta primary afferent terminals in the ipsilateral gracile ...
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